Research Associate I/II - Guide Screening

Metagenomi in Emeryville, California, United States

$70,000 - $95,000

We are seeking a motivated individual for a Research Associate I/II position focused on understanding the activity and specificity of novel gene editing systems in mammalian cells. This person will use their strong molecular and cell biology skills to solve a variety of challenges as an integral part of the Genome Editing team. Candidates should be enthusiastic, passionate, have attention to detail, and a desire to change the world. This role will be based in Emeryville, California.

How you’ll contribute:

  • Perform routine experiments to screen new genome editing technologies in immortalized mammalian cell lines and primary cells in a high throughput manner
  • Execute established gene editing SOPs and protocols that involve the following aspects to generate high quality data and present findings to stakeholders:
    • Cell Culture
    • Transfection
    • gDNA extraction
    • PCR
    • NGS Data analysis
  • Maintain complete and well organized documentation of all experiments
  • Collaborate with Pre-Clinical Therapeutic teams, Discovery, Automation, RNA Biology and NGS to deliver on project milestones and meet anticipated timelines
  • Prepare accurate and timely data summaries and contribute to writing of reports, papers, and patent manuscripts


What you bring:

  • BS or MS in biology, genetics, molecular biology or a related discipline required
  • At least two years of relevant experience in a laboratory setting that includes:
    • Transfecting mammalian cells using electroporation
    • Experience performing 96-well plate-format assays
    • Experience analyzing and interpreting NGS data
  • Excellent time management and organizational skills to keep up with demand of requests coming into the team. Ability to prioritize workload efficiently.
  • Ability to think strategically, manage time and workflow, and work independently as well as in a results-oriented operations team
  • Track record of challenging oneself to enhance scientific skills and knowledge
  • Highly collaborative, solutions oriented, and thrives in a fast-moving startup environment
  • Preferred additional qualifications
    • Experience transfecting primary cells using lipofection and/or LNPs
    • Experience working in a service/support based team, focused on processing requests/orders and reporting results to stakeholders.

California Pay Transparency Disclosure:

This position is classified as an exempt position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $70,000 - $95,000 .  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.

Please note, all candidates must be authorized to work in the United States.

About Metagenomi

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.

What makes Metagenomi a unique place to work?

  • We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.
  • We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!
  • We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.

At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.

Applicants/Employees have rights under various State and Federal Employment Laws, including

without limitation:

Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.

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