We are seeking a creative and collaborative Scientist, Gene Editing Systems to join the Discovery division and develop novel gene editing systems into therapeutic tools.
This position reports to the Lead of the CRISPR transposase team and will play a crucial role in translating systems discovered from nature into next-generation tools for performing accurate and efficient targeted genomic integrations.
This will involve developing cell based assays and readouts, performing functional genomics and library based screening, and optimizing systems for use in primary cells. You will have the opportunity to make a lasting impact as you partner with the automation, genome editing, and pre-clinical teams in order to establish the technology behind novel genetic medicines. This role will be based in Emeryville, California.
About the Role
- Design and generate protein expression constructs to test novel CRISPR-Cas systems in vitro and in mammalian cells
- Perform first-of-its-kind experiments to validate activity of novel gene editing systems
- Develop assays to characterize the activity of novel enzyme systems to determine editing outcomes and efficiencies
- Prepare accurate and timely data summaries; contribute to writing of reports, patents, manuscripts, and present findings to key stakeholders.
Desired Qualifications
- Ph.D in Molecular, Cell Biology, Genetics, or a related discipline
- Experience with CRISPR/Cas, transposons, Lentiviruses, and/or other gene editing technologies
- Experience with flow cytometry, qPCR, ddPCR, and/or NGS as readouts of cell editing
- Demonstrated track record of assay development and problem solving
- Effective oral and written communication, prioritization and organizational skills
- Able to quickly learn new software tools (Geneious, Crispresso, Slack)
- Highly collaborative, solutions oriented, and thrives in a fast-moving startup environment
California Pay Transparency Disclosure:
This position is classified as an exempt position under the Federal Labor Standards Act. The anticipated base salary range for this position will be $115,000 to $130,000 . You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.
At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law.
Please note, all candidates must be authorized to work in the United States.
About Metagenomi
Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.
What makes Metagenomi a unique place to work?
- We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.
- We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!
- We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.
At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.
Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.